Spatial Logic and Evolutionary Innovation in Human Placentation
Zhida Luo, Cheng Wang, Yan Zhou, Tuhin Kumar Guha, Purnima Narasimhan, Selina Lao Mason, Areca Smit, Xiaofei Sun, Michael P. Snyder, Gary Michael Shaw, David K. Stevenson, Antonina I. Frolova, Sarah K. England, Virginia D. Winn, Susan J. Fisher, Jingjing Li
The paper uses single-nucleus RNA-seq and spatial transcriptomics to show how the maternal-fetal interface diverges in structure and function between the basal plate and chorionic membranes, identifying NID2 as an ancestry-associated regulator of trophoblast invasion.
bioRxiv · Sep 9, 2026 · PreprintGenomics