Virginia D. Winn

The paper uses single-nucleus RNA-seq and spatial transcriptomics to show how the maternal-fetal interface diverges in structure and function between the basal plate and chorionic membranes, identifying NID2 as an ancestry-associated regulator of trophoblast invasion.

This study identifies persistent immune dysregulation in women with hypertensive disorders of pregnancy years after delivery, linked to increased cardiovascular disease risk.

The paper identifies CXCL12 as a genetic driver of coronary artery anatomy variation through GWAS and mouse models, showing its role in fetal coronary development.

This study creates a comprehensive single-cell atlas of the maternal-fetal interface, identifying cell-type-specific dysregulation in pregnancy complications.

This study uses single-cell transcriptomics to identify gene regulatory networks and lineage trajectories in human fetal thymic epithelial cells, revealing interferon response pathways that distinguish thymic epithelium from other anterior foregut-derived organs.

The paper shows that coronary endothelial cells in mouse and human hearts initially show lineage-specific transcriptional differences but later become influenced by location, with adult cells becoming more homogeneous.

The paper constructs a spatiotemporal atlas of the maternal-fetal interface using multiomic data to show how gestational age influences immune and stromal cell interactions and spiral artery remodeling.

This study identifies angiocrine factors secreted by endocardial and endothelial cells that regulate cardiomyocyte development and maturation, contributing to ventricular non-compaction in Ino80-deficient mouse hearts.

This study identifies changes in pregnancy-related serum biomarkers early in gestation as indicators of later preeclampsia development, validated in both human and mouse models.