Tuhin Kumar Guha

The paper uses single-nucleus RNA-seq and spatial transcriptomics to show how the maternal-fetal interface diverges in structure and function between the basal plate and chorionic membranes, identifying NID2 as an ancestry-associated regulator of trophoblast invasion.

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

The paper uses spatial CODEX experiments to show early colorectal cancer microenvironment changes in FAP, including CAFs, immune suppression, and beta-catenin nuclear translocation.

This study creates a comprehensive single-cell atlas of the maternal-fetal interface, identifying cell-type-specific dysregulation in pregnancy complications.

The paper develops a pipeline to profile both host expression and microbial abundance from spatial transcriptomic data, demonstrating host-microbe interactions and method efficiency.