Sarah K. England

The paper uses single-nucleus RNA-seq and spatial transcriptomics to show how the maternal-fetal interface diverges in structure and function between the basal plate and chorionic membranes, identifying NID2 as an ancestry-associated regulator of trophoblast invasion.

This study shows AVP activates AVPR1A in myometrial cells, inhibits SLO2.1 potassium channels, depolarizes cells, and enhances Ca²⁺ entry, increasing excitability and contraction.

This study investigates how maternal obesity affects fetal brain glucose transporter expression and energy-sensing pathways in mice, finding altered GLUT expression without changes in key regulatory pathways.

This study shows that fetoplacental circadian rhythms develop in utero and synchronize with the mother, with maternal glucocorticoids playing a key role in this synchronization.

Deleting Piezo1 and Piezo2 together in mice weakens uterine contractions and prolongs labor; uterine and sensory-neuron deletions act additively, and knockout uteri show reduced Gja1 (connexin43).

This study investigates the role of the SLO2.1/NALCN complex in regulating mouse myometrial smooth muscle cell membrane potential across pregnancy, finding its activity decreases as pregnancy progresses.

This paper develops a mathematical model to predict OXT-OXTR binding dynamics in different cell types and genetic variants, showing how dosing strategies can be optimized for personalized medicine.

This study creates a comprehensive single-cell atlas of the maternal-fetal interface, identifying cell-type-specific dysregulation in pregnancy complications.

This study shows fetal circadian rhythms develop early in pregnancy and synchronize with the maternal rhythm, influenced by maternal glucocorticoids.