Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis
Fumie Hayashi, Kristen Mittl, Ravi Dandekar, Josiah Gerdts, Ebtesam Hassan, Ryan D. Schubert, Lindsay Oshiro, Rita P. Loudermilk, Ariele L. Greenfield, Danillo G. Augusto, Gregory C Havton, Shriya Anumarlu, Arhan Surapaneni, Akshaya Ramesh, Edwina B. Tran, , Joseph J. Sabatino
Paired CSF and blood scRNA/TCR-seq in treatment-naive MS shows a small set of expanded, cytotoxic CSF-enriched CD8+ clonotypes, two of which recognize EBV epitopes.
Nature Immunology · Feb 5, 2026Peer-reviewedImmunology✦ In-depth digest