Danillo G. Augusto

Paired CSF and blood scRNA/TCR-seq in treatment-naive MS shows a small set of expanded, cytotoxic CSF-enriched CD8+ clonotypes, two of which recognize EBV epitopes.

MHConstructor provides a haplotype-informed, high-throughput pipeline for de novo MHC assembly from short read data, improving upon reference-based methods.

The paper develops C4Investigator, a bioinformatic pipeline for high-throughput analysis of C4 gene variants from genomic data, revealing high poly-allelic variation in the 1000 Genomes Project Dataset.

The paper creates a pan-MHC reference graph with 246 fully contiguous phased sequences, improving variant calling accuracy and population diversity representation.