Functional Analysis of Late-Onset Alzheimer's Disease Risk Genes in Caenorhabditis elegans Identifies Regulators of Neuronal Aging
Swapnil G. Waghmare, Meera M. Krishna, Emily C. Maccoux, Ariel L. Franitza, Brian A. Link, E Lezi
This study identifies LOAD risk gene homologs in C. elegans that modulate neuronal aging selectively in specific neuron classes, independent of lifespan, and highlights early endosomal and lipid pathways.
Translational Neurodegeneration · Jul 23, 2026Peer-reviewedNeuroscience