Brian A. Link

This study identifies LOAD risk gene homologs in C. elegans that modulate neuronal aging selectively in specific neuron classes, independent of lifespan, and highlights early endosomal and lipid pathways.

This study shows that deleting Llgl1 in cardiomyocytes disrupts intercalated disc integrity, causes electrical conduction defects, and allows cell cycle activity into adulthood, while improving cardiac function after injury.

This study shows that Clrn1 in Muller glia is critical for photoreceptor maintenance in USH3A, with controlled expression required to prevent cell death and degeneration.

This study shows that ablating mpeg+ macrophages worsens mfrp-related hyperopia in zebrafish, suggesting macrophages help mitigate hyperopia.

This study demonstrates that zebrafish can regenerate a functional RPE monolayer after widespread RPE ablation, with regeneration originating from peripheral RPE cells and requiring Wnt signaling.

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.

The paper shows that proteolytic cleavage of LRP2 on RPE cells modulates BMP signaling to control eye size and refractive error in zebrafish.

The paper shows that dense tissue packing and cell geometry regulate differentiation rate in zebrafish neural tube progenitors through Notch-dependent mechanisms.