NLP-12/Cholecystokinin signaling stabilizes sensory dendritic structure and protects neuronal healthspan in Caenorhabditis elegans
Meera M. Krishna, Swapnil G. Waghmare, Gabriel P. Phillips, Emily C. Maccoux, Tania Shaik, E Lezi
This study identifies NLP-12 as a neuropeptide that preserves neuronal structure and function in C. elegans by preventing excessive dendritic branching and maintaining proprioceptive ability during aging.
bioRxiv · Sep 25, 2026 · PreprintNeuroscience