Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling
Kasturi Biswas, Constance M. Moore, Hannah Rogers, Khursheed Alam Wani, Arjamand Mushtaq, Read Pukkila-Worley, Daniel P Higgins, Amy Karol Walker, Gregory P. Mullen, James B. Rand, Michael M. Francis
This study shows that cholinergic activation of G-protein-coupled receptor signaling is essential for transcriptional responses to chronic oxidative stress in C. elegans, linking cholinergic signaling to antioxidant defenses and neurodegenerative disease.
eLife · Jun 8, 2026Peer-reviewedNeuroscience