Hannah Rogers

Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

This study shows that cholinergic activation of G-protein-coupled receptor signaling is essential for transcriptional responses to chronic oxidative stress in C. elegans, linking cholinergic signaling to antioxidant defenses and neurodegenerative disease.

E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism

The paper shows that E. coli transcription factors regulate promoter activity through a universal homeostatic mechanism by stabilizing RNA polymerase in a context-dependent manner.