Read Pukkila-Worley

The paper identifies oleate depletion as a metabolic signal sensed by C. elegans to activate innate immunity against bacterial infection.

This study identifies kri-1/KRIT1 as a regulator that limits skn-1/NRF2 activity to control immune responses and lipid homeostasis in C. elegans, supporting reproductive health.

This study shows that cholinergic activation of G-protein-coupled receptor signaling is essential for transcriptional responses to chronic oxidative stress in C. elegans, linking cholinergic signaling to antioxidant defenses and neurodegenerative disease.

The paper identifies lysosomal integrity as a regulator of TIR-1/SARM1 aggregation, preventing toxic p38 immune activation in C. elegans.

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

This study shows that low S-adenosylmethionine (SAM) impairs stress-responsive transcription in C. elegans, affecting survival and gene regulation.