Amy Karol Walker

This study shows that cholinergic activation of G-protein-coupled receptor signaling is essential for transcriptional responses to chronic oxidative stress in C. elegans, linking cholinergic signaling to antioxidant defenses and neurodegenerative disease.

The paper investigates the functional specialization of SAM synthases in C. elegans, showing that SAMS-1 affects mitochondrial function and stress survival through phosphatidylcholine, while SAMS-4 is critical for methylation reactions.

This paper identifies DVE-1 as a transcriptional regulator that directs synapse elimination during GABAergic circuit remodeling in C. elegans by controlling the ubiquitin-proteasome system.

WormCat 2.0 identifies poorly annotated genes in C. elegans and shows they have human orthologs with limited annotation.

WormCat is a web-based tool for annotating and visualizing gene set enrichment in C. elegans datasets, identifying both known and novel biological categories.

This study shows that low S-adenosylmethionine (SAM) impairs stress-responsive transcription in C. elegans, affecting survival and gene regulation.