Suppression of nonsense mutations by small, cyclic peptides
Nanna Birkmose, Saleem Y. Bhat, Arpan Bhattacharya, Per Brinch Hansen, Thomas G. Andersen, Sophia Hunter, Emilie T. Larsen, Yale E. Goldman, Barry S. Cooperman, Charlotte Rohde Knudsen
This study identifies cyclic peptides that suppress nonsense mutations in yeast, showing high readthrough activity and low cytotoxicity, suggesting potential as novel therapeutics for genetic diseases.
bioRxiv · Apr 25, 2025 · PreprintMolecular Biology