Author

Saleem Y. Bhat

University of PennsylvaniaORCID 0000-0002-3744-003XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Barry S. CoopermaniD· 3 shared Yale E. GoldmaniD· 2 shared A.A. BhattacharyaiD· 1 shared Adam A. Jabak· 1 shared Arpan Bhattacharya· 1 shared Charlotte Rohde KnudseniD· 1 shared David M. ChenowethiD· 1 shared Emilie T. Larsen· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

Barry S. CoopermanORCID

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Author profile →

3 papers

Recent·Most cited

Mechanism-Based Discovery of New TRIDs Targeting Ribosome Pockets

Janeena Asuma, Hanfei Wang, Saleem Y. Bhat, Huile Zhu, Hong Li, Adam A. Jabak, David M. Chenoweth, Barry S. Cooperman

This paper identifies new TRIDs that target ribosome pockets to increase PTC readthrough, showing some are more potent than ataluren in vitro.

bioRxiv · Oct 21, 2026 · PreprintBiochemistry

Suppression of nonsense mutations by small, cyclic peptides

Nanna Birkmose, Saleem Y. Bhat, Arpan Bhattacharya, Per Brinch Hansen, Thomas G. Andersen, Sophia Hunter, Emilie T. Larsen, Yale E. Goldman, Barry S. Cooperman, Charlotte Rohde Knudsen

This study identifies cyclic peptides that suppress nonsense mutations in yeast, showing high readthrough activity and low cytotoxicity, suggesting potential as novel therapeutics for genetic diseases.

bioRxiv · Apr 25, 2025 · PreprintMolecular Biology

Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases

Saleem Y. Bhat, A.A. Bhattacharya, Hong Li, Xiaonan Cui, John D. Lueck, Yale E. Goldman, Barry S. Cooperman

This paper investigates how PTC identity and sequence context affect readthrough efficiency and ataluren's effectiveness, providing insights into patient-specific therapy design.

Nucleic Acids Research · Mar 7, 2025Peer-reviewedBiochemistry