A Transcriptomics-Based Computational Drug Repurposing Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis
Tomiko Oskotsky, Xinyu Tang, Erin Arthurs, Arpita Govil, Ferheen Abbasi, Arohee Bhoja, Daniel G. Bunis, Abby Lau, Jakob F. Einhaus, Maïgane Diop, Juan C. Irwin, Brice L Gaudilliere, David K. Stevenson, Linda C. Giudice, Stacy L. McAllister, Marina Sirota
This study identifies simvastatin and primaquine as potential therapeutics for endometriosis through computational drug repositioning, showing reduced pain and gene expression changes in animal models and lower disease risk in EMR data.
iScience · Aug 21, 2026Peer-reviewedBioinformatics