Linda C. Giudice

Simvastatin and Primaquine Identified as Potential Endometriosis Therapeutics via a Novel Epithelial-Stromal Assembloid Drug Screening Assay

The paper identifies simvastatin and primaquine as potential endometriosis treatments using human assembloids, showing significant reversal of disease-related gene expression pathways.

Predicting Endometriosis Status and Menstrual Cycle Phase Using DNA Methylation

This study uses DNA methylation data to predict endometriosis status and menstrual cycle phase, finding strong performance for cycle phase and moderate performance for endometriosis.

A Transcriptomics-Based Computational Drug Repurposing Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis

This study identifies simvastatin and primaquine as potential therapeutics for endometriosis through computational drug repositioning, showing reduced pain and gene expression changes in animal models and lower disease risk in EMR data.

Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing

CDRPipe integrates single-cell and bulk transcriptomic perturbation data to improve drug repurposing predictions by combining complementary resources.

Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface

This study compares transcriptomes of early onset preeclampsia and placenta accreta, finding inverse gene expression in key cell types and pathways at the maternal-fetal interface.

Genetic Variants in Recurrent Euploid Pregnancy Loss

The paper identifies genetic variants in 30 families with unexplained euploid pregnancy loss, finding monogenic causes in 25% of cases and expanding understanding of early human lethality.

Single-cell-level digital twins for preterm birth prevention strategies

The paper introduces SIMCO, a single-cell digital twin framework for evaluating PTL prevention drugs, identifying tetrahydrofolate, maprotiline, and aspirin-lansoprazole as top candidates.

Anticlustering for Sample Allocation To Minimize Batch Effects

The paper introduces anticlustering to balance batches and minimize batch effects in high-throughput sequencing, showing improved balance compared to existing methods.

Single-Cell Profiling Reveals Altered Endometrial Cellular Features Across the Menstrual Cycle in Endometriosis Patients

The paper uses single-cell transcriptomics to analyze endometrial cells from endometriosis patients, revealing altered cellular features and immune communication networks across the menstrual cycle.

A Multiomics, Spatiotemporal, and Single Cell Atlas for Mapping Cell-Type-Specific Dysregulation at the Maternal-Fetal Interface

This study creates a comprehensive single-cell atlas of the maternal-fetal interface, identifying cell-type-specific dysregulation in pregnancy complications.

Global Endometrial DNA Multi-omics Analysis Reveals Insights into mQTL Regulation and Associated Endometriosis Disease Risk

The paper analyzes endometrial DNA methylation and genetic variants to identify mQTLs and their association with endometriosis risk and menstrual cycle phases.

Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

This study identifies 13 novel genetic loci associated with endometriosis through a large GWAS meta-analysis and finds genetic links to other pain-related conditions.