Xinyu Tang

Simvastatin and Primaquine Identified as Potential Endometriosis Therapeutics via a Novel Epithelial-Stromal Assembloid Drug Screening Assay

The paper identifies simvastatin and primaquine as potential endometriosis treatments using human assembloids, showing significant reversal of disease-related gene expression pathways.

A Transcriptomics-Based Computational Drug Repurposing Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis

This study identifies simvastatin and primaquine as potential therapeutics for endometriosis through computational drug repositioning, showing reduced pain and gene expression changes in animal models and lower disease risk in EMR data.

Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing

CDRPipe integrates single-cell and bulk transcriptomic perturbation data to improve drug repurposing predictions by combining complementary resources.

Polyketide Synthase-Like Functionality Acquired by Plant Fatty Acid Elongase

The paper identifies a novel fatty acid elongation pathway in Orychophragmus limprichtianus that produces keto-hydroxy fatty acids via a polyketide synthase-like mechanism.

Simultaneous Isolation and Characterization of Lipoprotein Classes in Plasma, Including HDL Subclasses and the Uncharacterized Dense HDL

The paper describes a method to isolate and characterize lipoprotein classes in plasma, revealing unique lipidomic, proteomic, and small RNA signatures for each class.

Single-Cell Profiling Reveals Altered Endometrial Cellular Features Across the Menstrual Cycle in Endometriosis Patients

The paper uses single-cell transcriptomics to analyze endometrial cells from endometriosis patients, revealing altered cellular features and immune communication networks across the menstrual cycle.

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease

The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.