A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death
Meredith Nicole Nix, Sai P. Gourisankar, Kevin Bowman, Sabin A. Nettles, H H Yang, Brendan G. Dwyer, Roman C. Sarott, Hind Z. Abuzaid, Michael M. Martinez, Nick A. Phillips, Vincent Cabaud Gibouin, Artur Hakobyan, Vahram Arakelov, Garik Petrosyan, Aram Davtyan, , Gerald R. Crabtree
This paper develops KAT-TCIPs to induce cell death in diffuse large B cell lymphoma by redirecting p300 and CBP to activate programmed cell death genes repressed by BCL6.
Cell · Jul 20, 2026Peer-reviewedCancer Biology