Daniel Fernández

Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies

This study identifies hr2.016, a potent and broad SARS-CoV-2 neutralizing antibody, and shows its neutralization depends on kinetic stability and avidity.

A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death

This paper develops KAT-TCIPs to induce cell death in diffuse large B cell lymphoma by redirecting p300 and CBP to activate programmed cell death genes repressed by BCL6.

A small molecule PTER-selective inhibitor reduces food intake and body weight

This study identifies a PTER inhibitor that reduces food intake and body weight in mice, linking PTER function to obesity treatment.

Structure and ligand specificity of Borrelia burgdorferi BmpA

The paper determines the crystal structure of BmpA from Borrelia burgdorferi and identifies its ligand specificity for nucleosides.

ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

A small molecule blocks ENPP1, reviving immune attack on tumors and enhancing immune therapy with minimal side effects in preclinical cancer models.

Expression, purification, and characterization of diacylated Lipo-YcjN from Escherichia coli

This study determines the crystal structure of YcjN from E. coli, identifies its posttranslational diacylation, and explores its aggregation properties in solution.

Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness of Enterococcus faecalis

This study identifies two quorum-sensing systems in E. faecalis that regulate purine biosynthesis, enhancing its pathogenicity in macrophages and murine infections.

Chemical precision glyco-mutagenesis by glycosyltransferase engineering in living cells

The paper introduces a method to chemically tag glycans in living cells using engineered glycosyltransferases to study glycan structure and biosynthesis.