Sabin A. Nettles

A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death

This paper develops KAT-TCIPs to induce cell death in diffuse large B cell lymphoma by redirecting p300 and CBP to activate programmed cell death genes repressed by BCL6.

Activating p53Y220C with a Mutant-Specific Small Molecule

This paper develops a small molecule, TRAP-1, that activates mutant p53 by forming a ternary complex with BRD4, leading to p53 target gene upregulation and inhibition of cancer cell growth.

Synaptic Activity Causes Minute-scale Changes in BAF Complex Composition and Function

The paper investigates how synaptic activity rapidly alters BAF complex composition and function in neurons, revealing phosphorylation and chromatin remodeling effects within minutes.

MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes

This study identifies a functional interaction between MeCP2 and TOP2β in neurons, showing MeCP2 inhibits TOP2β activity at long genes, which may contribute to neurodevelopmental disorders.

NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

The paper shows NSD1 deposits H3K36me2 to pattern non-CG DNA methylation in neurons, linking this to neurodevelopmental disorders.

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disorders

This study shows that DNMT3A mutations cause behavioral and epigenomic changes in mice, similar to human neurodevelopmental disorders, by disrupting non-CG DNA methylation.