Delivery of defective interfering RNA antivirals to the lungs using hyperbranched poly(beta-amino ester) nanoparticles
Shun Yao, Jason Atkins, Priya Dhole, Ines Pena‐Novas, Julien H. Arrizabalaga, Arun K Sharma, Krishne Gowda, Daniel J. Hayes, Gabriella Worwa, Jens H. Kuhn, Marco Archetti
This study evaluates hPBAE nanoparticles for delivering diRNA antivirals to the lungs, showing efficient uptake, nuclease resistance, and safety in golden hamsters.
bioRxiv · May 29, 2026 · PreprintMicrobiology