A 667-nucleotide sequence in the SARS-CoV-2 nsp15 coding region promotes genome encapsidation
Shun Yao, Abhinay Gontu, Jason Atkins, Maurice Byukusenge, Padmaja Jakka, Gabriella Worwa, Jens H. Kuhn, Suresh Varma Kuchipudi, Marco Archetti
The paper identifies a 667-nucleotide region in SARS-CoV-2 nsp15 that binds nucleoprotein and enhances defective genome accumulation, revealing a new packaging signal element.
bioRxiv · May 29, 2026 · PreprintMicrobiology