Jens H. Kuhn

The paper proposes a genetic divergence threshold for demarcating orthoflavivirus species, identifying 25 new Euflavivirus and 33 new Fusivirus species.

The paper demonstrates the use of microfluidic lung organ-on-chips to model NiV infection and evaluate antiviral treatments in a biosafety level 4 lab.

The paper traces the origin of a cruise ship hantavirus pulmonary syndrome outbreak to a specific geographic corridor in the Andes using genomic analysis of Andes virus sequences.

This paper organizes a community challenge to develop automated virus taxonomy classification tools and evaluates their performance on a combined dataset of expert-curated and metagenomic sequences.

The paper identifies a 667-nucleotide region in SARS-CoV-2 nsp15 that binds nucleoprotein and enhances defective genome accumulation, revealing a new packaging signal element.

This study evaluates hPBAE nanoparticles for delivering diRNA antivirals to the lungs, showing efficient uptake, nuclease resistance, and safety in golden hamsters.

The paper shows influenza A virus infection increases global ADP-ribosylation, which inhibits viral replication, and identifies PARP1 as the main enzyme involved, with NS1 counteracting this effect.

This paper develops a deep learning-based method to quantify infectious viruses using cytopathic effect area analysis, improving throughput and reducing manual bias.

The paper identifies and characterizes RNA viruses in permafrost soil over four years, showing their diversity is structured by habitat and linked to greenhouse gas emissions.

The paper redefines the taxonomy of Flaviviridae by integrating protein sequence and structure data, revealing new clades and expanding host range.

This paper develops a CRISPR knockout screening method using viral replicons to identify host factors essential for viral replication, successfully identifying known and novel genes for dengue, chikungunya, and Ebola viruses.

This study identifies thalamo-frontal alpha band connectivity patterns in Tourette Syndrome using DBS and EEG, linking reduced connectivity to tic severity and pre-tic dynamics.

The paper uses protein structure modeling to analyze the evolutionary relationships and functional domains of eukaryotic DNA viruses with double jelly-roll capsids, revealing their origin and evolution.

The paper identifies increased transmissibility in MPXV clade IIb by analyzing genomic low-complexity regions (LCRs) and suggests they may be more informative than SNPs.

This study identifies functional connectivity patterns associated with tic reduction in Tourette Syndrome patients undergoing thalamic deep brain stimulation.

This paper introduces vConTACT 2.0, a network-based tool for prokaryotic virus taxonomy that scales to large datasets and achieves high accuracy in taxonomic assignments.

This study shows Ebola virus can infect boa constrictor cells without causing cytopathic effect or requiring genomic adaptation, while Marburg virus cannot.