Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish
Yosuke Ono, Martin Peterka, Michael I. Love, Amir Khan, Felix Bowers, Ashish Bhandari, Euan Gordon, Jonathan S. Ball, Chrissy L. Hammond, Charles R. Tyler, Steve Rees, Mohammad Bohlooly‐Y, Marcello Maresca, Steffen Scholpp
This study uses Prime Editors in zebrafish to achieve precise DNA insertion and substitution without exogenous donor DNA, showing higher efficiency for short modifications with nuclease-based PEn.
eLife · Jul 7, 2026Peer-reviewedMolecular Biology