Jonathan S. Ball

Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

This study uses Prime Editors in zebrafish to achieve precise DNA insertion and substitution without exogenous donor DNA, showing higher efficiency for short modifications with nuclease-based PEn.

Evaluating anaesthetics for improving scientific research and welfare using larval zebrafish

The paper evaluates six anaesthetics for their efficacy and tolerability in larval zebrafish, identifying MS222 and quinaldine sulfate as most suitable for deep anaesthesia and etomidate for cardiovascular studies.

Ethanol down-regulates gastrula gene expression and cell movement, causing symptoms of foetal alcohol spectrum disorders

This study shows ethanol disrupts gastrula gene expression and cell movement in zebrafish, leading to developmental defects similar to human FASDs.

A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery

The paper identifies three genes associated with heart failure using human exome sequencing and validates their roles in cardiovascular function using zebrafish CRISPR/Cas9 mutagenesis.