Author

Steve Rees

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:zebrafish· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Mohammad Bohlooly‐YiD· 3 shared Charles R. TyleriD· 2 shared Jonathan S. BalliD· 2 shared Marcello MarescaiD· 2 shared Steffen ScholppiD· 2 shared Yosuke OnoiD· 2 shared Amir Khan· 1 shared Amir Taheri‐GhahfarokhiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMolecular Biology

Mohammad Bohlooly‐YORCID

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Author profile →

3 papers

Recent·Most cited

Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

Yosuke Ono, Martin Peterka, Michael I. Love, Amir Khan, Felix Bowers, Ashish Bhandari, Euan Gordon, Jonathan S. Ball, Chrissy L. Hammond, Charles R. Tyler, Steve Rees, Mohammad Bohlooly‐Y, Marcello Maresca, Steffen Scholpp

This study uses Prime Editors in zebrafish to achieve precise DNA insertion and substitution without exogenous donor DNA, showing higher efficiency for short modifications with nuclease-based PEn.

eLife · Jul 7, 2026Peer-reviewedMolecular Biology

Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing

Sandra Wimberger, Nina Akrap, Mike A. Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, , Marcello Maresca

This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.

Nature Communications · Aug 14, 2023Peer-reviewedMolecular Biology

A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery

Matthew J. Winter, Yosuke Ono, Jonathan S. Ball, Anna Walentinsson, Erik Michaëlsson, Anna Tochwin, Steffen Scholpp, Charles R. Tyler, Steve Rees, Malcolm J. Hetheridge, Mohammad Bohlooly‐Y

The paper identifies three genes associated with heart failure using human exome sequencing and validates their roles in cardiovascular function using zebrafish CRISPR/Cas9 mutagenesis.

Frontiers in Pharmacology · Apr 25, 2022Peer-reviewedMolecular Biology