Steffen Scholpp

Lost and found: beer belly is a novel, ancient regulator of animal development

The paper identifies a novel gene, beer belly, as a regulator of segmentation in spiders using single-cell RNA sequencing and shows its evolutionary loss in mammals and holometabolous insects.

Calcium signals at cytoneme contacts amplify Wnt/β-catenin signalling

This study shows that calcium signals at cytoneme contacts enhance Wnt/β-catenin signaling by stabilizing cell interactions and promoting signalosome formation.

Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

This study uses Prime Editors in zebrafish to achieve precise DNA insertion and substitution without exogenous donor DNA, showing higher efficiency for short modifications with nuclease-based PEn.

Rab8a-positive vesicles transport Wnt8a along cytonemes in zebrafish embryogenesis.

The paper shows Rab8a-dependent vesicular trafficking transports Wnt8a along cytonemes in zebrafish embryos, affecting Wnt signaling and embryonic patterning.

Amyloid-β can activate JNK signalling via WNT-5A/ROR2 to reduce synapse formation in Alzheimer's disease.

This study shows that Amyloid-β activates JNK signaling through WNT-5A/ROR2, reducing synapse formation in Alzheimer's disease.

Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons.

The paper shows that Wnt-7a signaling from dendritic filopodia, combined with calcium signaling, is essential for synapse formation in cortical neurons.

A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery

The paper identifies three genes associated with heart failure using human exome sequencing and validates their roles in cardiovascular function using zebrafish CRISPR/Cas9 mutagenesis.

Cytoneme-mediated transport of active Wnt5b/Ror2 complexes in zebrafish gastrulation

The paper demonstrates that Wnt5b/Ror2 complexes are transported via cytonemes to trigger Wnt/PCP signaling in zebrafish gastrulation, independent of receptor expression.

Vangl2 regulates the dynamics of Wnt cytonemes in vertebrates

This study shows that Vangl2 regulates cytoneme dynamics, affecting Wnt/{beta}-catenin signaling and tissue patterning in vertebrates.

Pcdh18a-positive tip cells instruct notochord formation in zebrafish

The paper identifies Pcdh18a-positive tip cells that guide notochord formation in zebrafish through migration and signaling.

Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms

The paper develops a method to image subcellular dynamics in vivo using lattice light sheet microscopy and adaptive optics, revealing phenotypic diversity across organisms and developmental stages.