Chrissy L. Hammond

Ibuprofen impairs fracture healing by disrupting neutrophil-mediated tissue repair

Distinct roles for TANGO1S domains in maintaining ER-Golgi architecture

This study investigates the functional roles of TANGO1S domains in maintaining ER-Golgi architecture by analyzing domain-deletion mutants in knockout cells.

Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

This study uses Prime Editors in zebrafish to achieve precise DNA insertion and substitution without exogenous donor DNA, showing higher efficiency for short modifications with nuclease-based PEn.

Nanovibrational stimulation preferentially enhances osteogenic responses in zebrafish

This study shows nanovibrational stimulation preferentially enhances osteogenic responses in zebrafish without significantly affecting other tissues.

Loss of lmx1ba drives premature osteoarthritis through disruption of skeletal homeostasis

This study shows that loss of lmx1ba in zebrafish causes premature osteoarthritis by disrupting skeletal homeostasis and joint maintenance in adult life.

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

This paper introduces coagulative granular hydrogels stabilized by enzyme-catalyzed fibrin networks to enhance mechanical integrity and support tissue regeneration.

Deep leaning auto-segmentation of tomographic datasets, repeatability and biomechanical outcomes

This paper develops a deep learning framework for automated segmentation of 3D CT data and validates its biomechanical accuracy using zebrafish mandibles.

TELOMERASE DEPLETION ACCELERATES AGEING OF THE ZEBRAFISH BRAIN

This study shows that telomerase deficiency in zebrafish accelerates brain ageing by promoting senescence, inflammation, and blood-brain barrier dysfunction.

Characterisation of lmx1b paralogues in zebrafish reveals divergent roles in skeletal, kidney, and muscle development

The paper characterizes lmx1b paralogues in zebrafish, revealing distinct roles in skeletal, kidney, and muscle development, and identifies a new role in notochord cell inflation.

The growth-promoting protein TMEM263 is an ER resident that controls early stages of lipid droplet biogenesis

This study identifies TMEM263 as an ER-resident protein essential for lipid droplet formation and growth, showing its role in lipid condensation and organismal development.

Tuning Collective Behaviour in Zebrafish with Genetic Modification

This study genetically modifies zebrafish to demonstrate how altering individual traits can tune collective behavior, showing mutant fish exhibit more orderly motion than wildtype.

Cyclical compression loading is the dominant mechanoregulator of synovial joint morphogenesis

This study identifies cyclical compression loading as critical for normal joint morphogenesis in zebrafish, showing that dynamic mechanical stimuli, not static compression, regulate joint shape and growth.

Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish

This study uses computational modeling to show that growth orientation, not growth rate, primarily drives jaw joint morphogenesis in larval zebrafish.

The transcriptome of regenerating zebrafish scales identifies genes involved in human bone disease

The paper identifies genes involved in human bone disease by analyzing transcriptomic changes during zebrafish scale regeneration.

Autophagy coordinates chondrocyte development and early joint formation in zebrafish

This study shows that autophagy is essential for proper chondrocyte maturation and joint formation in zebrafish, with its disruption causing premature hypertrophy and developmental defects.

Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

The paper shows transformed notochordal cells in zebrafish cause skeletal damage, chronic wound-like responses, and bone homeostasis disruption, linking chordomas to inflammation and IVD degeneration.

NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss

The paper identifies NCOA3 as a candidate gene for autosomal dominant progressive hearing loss through linkage analysis and functional studies in zebrafish.

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

A rare SMAD9 mutation is linked to high bone mass, suggesting the BMP pathway as a potential osteoanabolic target.

The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function which lead to early onset osteoarthritis

This study examines the effects of col11a2 loss in zebrafish on joint development and function, showing increased stiffness and early onset osteoarthritis.

Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth

This study shows that zebrafish lacking sp7 can replace teeth without attachment bone, but with poor differentiation and abnormal tooth orientation.

Wnt Signalling Controls the Response to Mechanical Loading during Zebrafish Joint Development

This study shows that Wnt signaling mediates mechanical strain responses during zebrafish joint development, affecting cell proliferation and migration but not chondrocyte intercalation.

A zebrafish model of developmental joint dysplasia: Manipulating the larval mechanical environment to drive the malformation and recovery of joint shape

This paper develops a zebrafish model to study joint dysplasia by manipulating the mechanical environment, identifying cellular factors that predict recovery of joint shape and function.

The Golgi matrix protein giantin is required for normal cilia function in zebrafish

This study shows that loss of giantin in zebrafish causes cilia function defects, with morphants showing fewer cilia and mutants having elongated cilia.