Aged blood inhibits hippocampal neurogenesis and activates microglia through VCAM1 at the blood-brain barrier
Hanadie Yousef, Cathrin J. Czupalla, Davis P. Lee, Ashley Burke, Michelle Chen, Judith Zandstra, Elisabeth Berber, Benoit Lehallier, Vidhu Mathur, Ramesh V. Nair, Liana N. Bonanno, Taylor Merkel, Markus Schwaninger, Stephen R. Quake, Eugene C. Butcher, Tony Wyss‐Coray
This study shows aged blood reduces hippocampal neurogenesis and activates microglia via VCAM1 at the BBB, and blocking VCAM1 reverses these effects.
bioRxiv · Jan 3, 2018 · PreprintNeuroscience