Markus Schwaninger

Gαq/11 signalling counteracts endothelial dysfunction in the brain and protects cognition in aged mice

This study shows that Gαq/11 signaling in brain endothelial cells prevents endothelial dysfunction and cognitive decline in aged mice by maintaining vascular reactivity and preventing blood-brain barrier disruption.

Distinct Effects of Aging and Klotho Deletion on the Choroid Plexus

This study examines how aging and Klotho deletion affect choroid plexus structure and function, finding that Klotho deficiency increases age-related calcification in specific regions.

Ciliary sensing in tanycytes couples nutrient availability to metabolic regulation

This study shows that tanycytic cilia sense metabolic cues in the cerebrospinal fluid, affecting energy balance and metabolism in mice.

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

This paper introduces a high-speed light sheet microscope with isotropic sub-micron resolution for cleared tissue imaging, achieving 850 nm resolution across 1 cm3 samples.

Endothelial and neuronal engagement by AAV-BR1 alleviates neurological symptoms and cholesterol deposition in a mouse model of Niemann-Pick type C2

AAV-BR1-NPC2 gene therapy reduces cholesterol deposition and neurological symptoms in NP-C2 mice by delivering NPC2 to brain endothelial cells and neurons.

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

This study demonstrates that gene therapy targeting brain endothelial cells improves neurological symptoms in a mouse model of MCT8 deficiency by increasing brain T3 levels and motor function.

Maternally inherited differences within mitochondrial Complex I control murine healthspan.

This study shows that a mutation in mt-Nd2, a mitochondrial complex I gene, reduces lifespan and increases glucose intolerance in mice by affecting tryptophan levels and aging pathways.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.

Aged blood inhibits hippocampal neurogenesis and activates microglia through VCAM1 at the blood-brain barrier

This study shows aged blood reduces hippocampal neurogenesis and activates microglia via VCAM1 at the BBB, and blocking VCAM1 reverses these effects.