Ramesh V. Nair

Gene therapy targeting of AKAP6β-CaMKII signalosomes improves myocardial inflammation and heart failure in a swine model of cardiometabolic syndrome

Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases

This study identifies sex-specific changes in bone and senescence-related proteins in neurodegenerative diseases using plasma proteomics.

Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotype

The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.

CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

Regulation of the Balance between Concentric and Eccentric Cardiac Hypertrophy by a CDC14A-KMT5A Signaling Pathway

This paper identifies CDC14A and KMT5A as regulators of concentric vs. eccentric cardiac remodeling through epigenomic control of gene transcription, with CDC14A as a potential therapeutic target for heart failure.

LOSS OF ROR2 TYROSINE KINASE RECEPTOR IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN PAH VIA INAPPROPRIATE INTEGRIN BETA 1 ACTIVATION

This study shows that loss of ROR2 leads to endothelial dysfunction in PAH through inappropriate integrin beta 1 activation, impairing barrier integrity and angiogenesis.

Single Cell RNA Sequencing Analysis of Human Melanoma Reveals A Distinct Prognostic Myeloid Cell

This study identifies six myeloid cell clusters in melanoma using scRNA-seq, finding that M_C1 subtype frequency predicts survival and immunotherapy response.

Genome-Wide Transcription Response of Staphylococcus epidermidis to Heat Shock and Medically Relevant Glucose Levels

This study quantifies gene expression changes in Staphylococcus epidermidis under varying glucose and temperature conditions, identifying glucose-responsive genes and a heat-shock response similar to related species.

Personalized transcriptome signatures in a cardiomyopathy stem cell biobank

The paper establishes a cardiomyopathy stem cell biobank and identifies transcriptomic subtypes and drug response in iPSC-derived cardiomyocytes.

Newly repopulated spinal cord microglia exhibit a unique transcriptome and correlate with pain resolution

The paper shows that newly repopulated spinal cord microglia have a unique transcriptome linked to pain resolution in a tibial fracture model.

KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear Stress

The paper shows how KLF4 interacts with SWI/SNF to increase chromatin accessibility at enhancers under laminar shear stress, promoting endothelial homeostasis and suppressing inflammation.

A microRNA cluster downstream of the selector gene Fezf2 coordinates fate specification with dendritic branching in cortical neurons

The paper shows that the miR-193b~365 microRNA cluster downstream of Fezf2 represses Mapk8 and affects dendritic branching in cortical projection neurons.

An evolutionarily acquired microRNA shapes development of mammalian cortical projections

The paper identifies a microRNA cluster unique to placental mammals that promotes corticospinal neuron identity by repressing LMO4, a callosal gene, thereby contributing to neuronal subtype diversity in the mammalian brain.

NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells

This study identifies NF90/ILF3 as a transcription factor that promotes proliferation over differentiation in K562 cells by hierarchically regulating key transcription factors.

Aged blood inhibits hippocampal neurogenesis and activates microglia through VCAM1 at the blood-brain barrier

This study shows aged blood reduces hippocampal neurogenesis and activates microglia via VCAM1 at the BBB, and blocking VCAM1 reverses these effects.