Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer's disease
Abigail E Cullen, Nick R Winder, Byron Lee, Sahana Krishna Kumaran, Nayantara Arora, Julia R Wolf, Grant D Henson, Randy L Woltjer, Ashley E Walker
This study shows that Robo4 deletion increases neuroinflammation and impairs motor coordination in Alzheimer's disease mice, with effects dependent on AD mutations and brain region.
bioRxiv · Mar 7, 2024 · PreprintPhysiology