Abigail E. Cullen

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunction

This study uses a humanized Aβ mouse model to show that E4 genotype leads to cognitive impairments, microglial activation, and cerebrovascular dysfunction, with greater effects in females.

APOE4 genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice

This study investigates how APOE4 genotype and old age interact to affect cerebrovascular function, brain volume, and neuroinflammation in mice, finding that the interaction impacts these outcomes while age alone affects cognitive function and arterial stiffness.

The Impact of Age and Sex on Cerebral and Large Artery Stiffness and the Response to Pulse Pressure

This study examines how age and sex affect cerebral and large artery stiffness and their response to pulse pressure in mice, finding that young females have more compliant arteries susceptible to endothelial dysfunction.

Cerebral blood flow in elastin haploinsufficient and 3xTg-AD mice

This study examines cerebral blood flow and reactivity in elastin haploinsufficient and 3xTg-AD mice, finding impaired cerebrovascular reactivity in combined genotypes.

APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.

Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer's disease

This study shows that Robo4 deletion increases neuroinflammation and impairs motor coordination in Alzheimer's disease mice, with effects dependent on AD mutations and brain region.