The hyaluronan-binding activity of aggrecan is important, but not essential, for its specific insertion into perineuronal nets
Matthew Y. Otsuka, Leslie Brian Essel, Ashis Sinha, Gabrielle A. Nickerson, Seth M. Mejia, Ashley Edge, Russell T. Matthews, Samuel Bouyain
This study reports the co-crystal structure of aggrecan's G1 region with and without HA and shows that HA-binding is important but not essential for its integration into perineuronal nets.
Journal of Biological Chemistry · Apr 22, 2025Peer-reviewedBiochemistry