Enabling functionality and translation fidelity characterization of mRNA-based vaccines with a platform-based, antibody-free mass spectrometry detection approach
Alyssa Q. Stiving, Benjamin W. Roose, Christopher M. Tubbs, Mark A. Haverick, Ashley Gruber, Richard R. Rustandi, Jesse L. Kuiper, Matthew W. Schombs, Hillary A. Schuessler, Xuanwen Li
This paper develops an antibody-free mass spectrometry method to assess mRNA vaccine functionality and translation fidelity using cell-free translation and LC-MS.
npj Vaccines · Feb 23, 2025Peer-reviewedBiochemistry