Differential effects of two common GVHD prophylaxis regimens on the gut microbiome: Results from the BMT CTN 1801 study
Jakob Wirbel, Wael Saber, Michael J. Martens, Jonathan U. Peled, Tessa M. Andermann, Teng Fei, Erin F. Brooks, Boryana Doyle, Nathan B. Pincus, Robert R. Jenq, Merav Bar, Javier Bolaños‐Meade, Brandi Bratrude, Saurabh Chhabra, Sung Won Choi, , Ami Siddharth Bhatt
This study compares the effects of two GVHD prophylaxis regimens on the gut microbiome in allo-HCT recipients and finds that while PTCy reduces microbiome diversity and bile acid metabolism, it is linked to better clinical outcomes.
bioRxiv · Feb 20, 2026 · PreprintMicrobiology