Jonathan U. Peled

Sugar-rich foods exacerbate antibiotic-induced microbiome injury

The paper links sugar-rich foods to microbiome disruption during antibiotic treatment in patients and mice.

Dietary fiber intake associates with improved survival and microbiomecomposition in allogeneic hematopoietic cell transplantation

This study shows that higher dietary fiber intake improves survival and reduces GVHD in hematopoietic cell transplant patients, with microbiome-mediated effects.

Ecological determinants of disease and immunity in myelodysplastic syndromes

This study uses spatial transcriptomics and single-cell analysis to reveal how MDS bone marrow microenvironments are altered, showing TGFβ dysregulation in malignant cells and immune escape mechanisms.

Metabiosis underlies a microbiota permissive to Pseudomonadota and increases the risk of gut-borne bloodstream infection

The paper identifies metabiosis, an ecological dependency where Bacteroides supports Pseudomonadota growth, increasing gut-borne bloodstream infection risk in allo-HCT patients.

Differential effects of two common GVHD prophylaxis regimens on the gut microbiome: Results from the BMT CTN 1801 study

This study compares the effects of two GVHD prophylaxis regimens on the gut microbiome in allo-HCT recipients and finds that while PTCy reduces microbiome diversity and bile acid metabolism, it is linked to better clinical outcomes.

Correlating High-dimensional longitudinal microbial features with time-varying outcomes with FLORAL

The paper introduces FLORAL, a method for analyzing longitudinal microbiome data to identify biomarkers associated with time-varying outcomes, showing improved sensitivity and FDR control in simulations and real-world applications.

Enhanced Feature Selection for Microbiome Data using FLORAL: Scalable Log-ratio Lasso Regression

FLORAL improves microbial feature selection for microbiome data by addressing survival endpoints, longitudinal samples, and sequencing biases, showing better false-positive control and sensitivity in simulations and real data.

Leucine zipper-based sorting system enables generation of multi-functional CAR T cells

This paper introduces a leucine zipper-based sorting system to generate T cells with multiple CARs and switch receptors, enhancing their ability to target heterogeneous tumors.

A compilation of fecal microbiome shotgun metagenomics from hospitalized patients undergoing hematopoietic cell transplantation

The paper compiles shotgun metagenomic data from stool samples of hospitalized hematopoietic cell transplant patients to enhance microbiome analysis beyond taxonomic composition.