Nav1.8 mediates peripheral-to-central nociceptive transmission independently of central presynaptic mechanisms in human DRG-spinal cord circuits
Seph M. Palomino, Katherin A. Gabriel, Ashwin Koduri, Ibrahim Khan, Syed Abdur Rahman, Peter Horton, Tariq Khan, Anna M. Cervantes, Geoffrey Funk, Stephanie I. Shiers, Theodore John Price, Amol M. Patwardhan
This study shows that Nav1.8 blockers reduce spinal CGRP release only when applied to peripheral sites, indicating their mechanism acts at the peripheral level rather than the central nervous system.
bioRxiv · Mar 3, 2026 · PreprintNeuroscience