Katherin A. Gabriel

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

This study shows that Nav1.8 blockers reduce spinal CGRP release only when applied to peripheral sites, indicating their mechanism acts at the peripheral level rather than the central nervous system.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

This study investigates the mechanism of BoNT/A1 in human sensory neurons, showing it disrupts SNARE complexes and reduces neurotransmitter release through transcriptomic analysis.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

This paper shows that inhibiting specific spinal cord Hsp90 isoforms enhances opioid pain relief while reducing tolerance and side effects.

This paper describes a non-viral CRISPR-Cas9 transfection method for editing primary human dorsal root ganglion neurons and confirms edits at genomic, protein, and functional levels.