Seph M. Palomino

Mimics of the chordate gut-brain hormone neurotensin in parasitic intestinal hookworms

This study identifies a new family of hookworm peptides that mimic the chordate gut-brain hormone neurotensin, showing structural and functional similarity to modulate gut function.

T-cell distribution in the dorsal root ganglion across species, sex, and age

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

Nav1.8 mediates peripheral-to-central nociceptive transmission independently of central presynaptic mechanisms in human DRG-spinal cord circuits

This study shows that Nav1.8 blockers reduce spinal CGRP release only when applied to peripheral sites, indicating their mechanism acts at the peripheral level rather than the central nervous system.

Prey-specific toxins provide broad venom activity in cephalopods

The paper identifies prey-specific toxins in cephalopod venom, including neurotensin-mimicking peptides that target fish, revealing an evolutionary strategy for broad venom activity.

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

Expansion of OSMR expression and signaling in the human dorsal root ganglion links OSM to neuropathic pain

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9 with functional confirmation

This paper describes a non-viral CRISPR-Cas9 transfection method for editing primary human dorsal root ganglion neurons and confirms edits at genomic, protein, and functional levels.

Functional NHE1 Expression is Critical to Blood Brain Barrier Integrity and Sumatriptan Blood to Brain Uptake

This study investigates the role of NHE1 in BBB integrity during CSD events and its impact on drug uptake, finding that NHE1 disruption affects BBB function and sumatriptan penetration.