IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2
Awalpreet Singh Chadha, Asif Elahi, Blake F. Frey, Yoshiko Nagaoka-Kamata, Carlene L. Zindl, Trenton R. Schoeb, Caleb R. Glassman, K. Christopher García, Casey Todd Weaver
This paper shows IL-23 licenses Th17 cells for transdifferentiation into pathogenic effectors by upregulating IL-12Rβ2 via STAT4, revealing a stepwise mechanism involving IL-23 and IL-12.
bioRxiv · Jul 26, 2026 · PreprintImmunology