Casey Todd Weaver

Ileitis abolishes tolerogenic functions of the enterohepatic bile acid pool

The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2

This paper shows IL-23 licenses Th17 cells for transdifferentiation into pathogenic effectors by upregulating IL-12Rβ2 via STAT4, revealing a stepwise mechanism involving IL-23 and IL-12.

Constitutive androstane receptor directs developing Th1 cells towards the Tr1 lineage

This study shows CAR promotes Tr1 lineage commitment in Th1 cells during intestinal inflammation, with IL-27 and glucocorticoids enhancing this effect.

Barrier Immune Memory is Promoted by Intestinal Epithelial Cell Presentation of Injected Bacterial Antigens

The paper shows that CD4 T cell memory is enhanced when antigens are presented by intestinal epithelial cells rather than bacterial proteins.

Probiotic biogeography and sepsis prevention in the neonatal intestine

This study investigates the probiotic effects of Escherichia coli Nissle 1917 and Ligilactobacillus murinus V10 in preventing Klebsiella pneumoniae sepsis in neonatal mice, showing that single-strain treatments are more effective than combinations.