Author

Blake F. Frey

University of Alabama at BirminghamORCID 0000-0003-3003-6904Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Casey Todd WeaveriD· 3 shared Carlene L. ZindliD· 2 shared Yoshiko Nagaoka-Kamata· 2 shared Akshaya BalasubramanianiD· 1 shared Asif Elahi· 1 shared Awalpreet Singh ChadhaiD· 1 shared B. JoNell Hamilton· 1 shared Caleb R. GlassmaniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Casey Todd WeaverORCID

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3 papers

Recent·Most cited

IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2

Awalpreet Singh Chadha, Asif Elahi, Blake F. Frey, Yoshiko Nagaoka-Kamata, Carlene L. Zindl, Trenton R. Schoeb, Caleb R. Glassman, K. Christopher García, Casey Todd Weaver

This paper shows IL-23 licenses Th17 cells for transdifferentiation into pathogenic effectors by upregulating IL-12Rβ2 via STAT4, revealing a stepwise mechanism involving IL-23 and IL-12.

bioRxiv · Jul 26, 2026 · PreprintImmunology

Constitutive androstane receptor directs developing Th1 cells towards the Tr1 lineage

Courtney Lynn Hegner, Blake F. Frey, Akshaya Balasubramanian, Henry D. Dionne, 楊惠娟, B. JoNell Hamilton, Casey Todd Weaver, Mark S. Sundrud

This study shows CAR promotes Tr1 lineage commitment in Th1 cells during intestinal inflammation, with IL-27 and glucocorticoids enhancing this effect.

bioRxiv · Jul 26, 2026 · PreprintImmunology

Barrier Immune Memory is Promoted by Intestinal Epithelial Cell Presentation of Injected Bacterial Antigens

Christopher Garrett Wilson, Pragun Acharya, Laura Karsch, Lennard Wayne Duck, Nana Twumasi-Ankrah, Yuanyou Wang, Hongxing Shen, Chuan Xing, Blake F. Frey, Vishal H. Oza, Stacey N. Harbour, Yoshiko Nagaoka-Kamata, Jeffrey R. Singer, Robin D. Hatton, Jeffrey R. Moffitt, , Casey Todd Weaver

The paper shows that CD4 T cell memory is enhanced when antigens are presented by intestinal epithelial cells rather than bacterial proteins.

bioRxiv · Mar 31, 2026 · PreprintImmunology