Predictive modeling provides insight into the clinical heterogeneity associated with TARS1 loss-of-function mutations
Rebecca Meyer‐Schuman, Allison R. Cale, Jennifer A. Pierluissi, Kira E. Jonatzke, Young Nyun Park, Guy M. Lenk, Stephanie N. Oprescu, Marina A. Grachtchouk, Andrzej Antoni Dlugosz, Asim A. Beg, Miriam H. Meisler, Anthony Antonellis
The paper investigates TARS1 loss-of-function mutations using engineered variants in yeast and mouse models, revealing new clinical phenotypes and heterogeneity.
bioRxiv · Mar 25, 2024 · PreprintGenetics