Author

Guy M. Lenk

University of MichiganORCID 0000-0001-8092-1405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Organism:yeast· 1

Frequent Co-Authors

Allison R. CaleiD· 1 shared Andrzej Antoni DlugosziD· 1 shared Anthony AntonellisiD· 1 shared Asim A. Beg· 1 shared Jennifer A. Pierluissi· 1 shared Kira E. Jonatzke· 1 shared Marina A. GrachtchoukiD· 1 shared MH Meisler· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Allison R. CaleORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintApr 28, 2026

CRISPR activation of PIKFYVE as potential therapy for FIG4 deficiency

Q Doctrove, Guy M. Lenk, VH LiPuma, MH Meisler

This study uses CRISPR activation to upregulate PIKFYVE in Fig4 deficient mice, showing that a 2-fold increase is insufficient to rescue lysosomal enlargement and survival.

DOI 10.64898/2026.04.24.718784

mouseexperimental assay

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GeneticsbioRxivPreprintMar 25, 2024

Predictive modeling provides insight into the clinical heterogeneity associated with TARS1 loss-of-function mutations

Rebecca Meyer‐Schuman, Allison R. Cale, Jennifer A. Pierluissi…·Anthony Antonellis

The paper investigates TARS1 loss-of-function mutations using engineered variants in yeast and mouse models, revealing new clinical phenotypes and heterogeneity.

DOI 10.1101/2024.03.25.586600

mouseyeast

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