Andrzej Antoni Dlugosz

This paper develops an immunocompetent mouse model of Merkel cell carcinoma that forms tumors and metastases, showing that LSD1 inhibitors effectively reduce tumor growth and metastasis.

This study develops an immunocompetent mouse model of liposarcoma that recapitulates human tumor subtypes and immune features, enabling preclinical immunotherapy research.

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

The paper identifies Meibomian gland stem cell populations and mechanisms of aging using mouse models and finds Hh signaling regulates stem cell proliferation, with decreased Hh and EGF signaling in aged glands.

The paper investigates TARS1 loss-of-function mutations using engineered variants in yeast and mouse models, revealing new clinical phenotypes and heterogeneity.

This study identifies distinct mechanisms for sebaceous gland self-renewal and regeneration, showing that injury triggers replacement by hair follicle-derived stem cells and FGFR-dependent regeneration.