Alveolar Type II Cell-derived MMP1high basal cells promote destructive microcysts in idiopathic pulmonary fibrosis.
Kiana Garakani, Alexis N. Brumwell, Marylène Toigo, Anjali Jacob, Ying Wei, Tsung Che Ho, Paul J. Wolters, Michael A. Matthay, Regan F. Volk, Balyn W. Zaro, Stefano A. Iantorno, Asres Mitke, Dean Sheppard, Vincent C. Auyeung, Claude Jourdan Le Saux, Harold A. Chapman
The paper identifies MMP1high basal cells derived from alveolar type II cells that contribute to microcyst formation in IPF, suggesting a therapeutic target through MMP inhibition or WNT modulation.
bioRxiv · Dec 11, 2025 · PreprintCell Biology