Author

Tsung Che Ho

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Claude Jourdan Le SauxiD· 3 shared Alexis N. BrumwelliD· 2 shared Harold A. ChapmaniD· 2 shared Kiana GarakaniiD· 2 shared Marylène Toigo· 2 shared Michael A. MatthayiD· 2 shared Paul J. WoltersiD· 2 shared Stefano A. IantornoiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

Claude Jourdan Le SauxORCID

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3 papers

Recent·Most cited

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF).

Stefano A. Iantorno, Ying Wei, Kiana Garakani, Alexis N. Brumwell, Tsung Che Ho, Marylène Toigo, Jaymin J. Kathiriya, Asres Berhan Mitke, Vivianne W. Ding, Zea Borok, Johannes Ruediger Kratz, Michael A. Matthay, Paul J. Wolters, Harold A. Chapman, Claude Jourdan Le Saux

This study identifies age-related epigenetic changes in AT2 cells that promote basal cell metaplasia, contributing to idiopathic pulmonary fibrosis.

bioRxiv · Jun 10, 2026 · PreprintCell Biology

Cellular senescence dysregulates antiviral interferon responses in idiopathic pulmonary fibrosis

Jun‐Wei B. Hughes, Yasmina Reisser, Franziska Hornung, Tyler A. U. Hilsabeck, Fiona Senchyna, A L Coelho, Tsung Che Ho, Kevin Schneider, David Furman, Cory M. Hogaboam, Claude Jourdan Le Saux, Pierre-Yves Desprez, Stefanie Deinhardt‐Emmer

This study shows that cellular senescence in IPF fibroblasts disrupts antiviral responses, leading to increased viral titers and altered inflammation.

bioRxiv · Apr 23, 2026 · PreprintCell Biology

Alveolar Type II Cell-derived MMP1high basal cells promote destructive microcysts in idiopathic pulmonary fibrosis.

Kiana Garakani, Alexis N. Brumwell, Marylène Toigo, Anjali Jacob, Ying Wei, Tsung Che Ho, Paul J. Wolters, Michael A. Matthay, Regan F. Volk, Balyn W. Zaro, Stefano A. Iantorno, Asres Mitke, Dean Sheppard, Vincent C. Auyeung, Claude Jourdan Le Saux, Harold A. Chapman

The paper identifies MMP1high basal cells derived from alveolar type II cells that contribute to microcyst formation in IPF, suggesting a therapeutic target through MMP inhibition or WNT modulation.

bioRxiv · Dec 11, 2025 · PreprintCell Biology