Ying Wei

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF).

This study identifies age-related epigenetic changes in AT2 cells that promote basal cell metaplasia, contributing to idiopathic pulmonary fibrosis.

Alveolar Type II Cell-derived MMP1high basal cells promote destructive microcysts in idiopathic pulmonary fibrosis.

The paper identifies MMP1high basal cells derived from alveolar type II cells that contribute to microcyst formation in IPF, suggesting a therapeutic target through MMP inhibition or WNT modulation.

Awakening prime editing for precision engineering of probiotic Escherichia coli Nissle 1917

This paper develops a streamlined prime editing system for Escherichia coli Nissle 1917, achieving high editing efficiencies and reduced off-target effects for DNA deletion, insertion, and substitution.

One-for-all gene inactivation via PAM-independent base editing in bacteria

This paper introduces XSTART, a PAM-independent base editing system for universal gene inactivation in bacteria, achieving near 100% efficiency but with off-target events.

Programmable marine bacteria catalyze the valorization of lignin monomers

This study reprograms marine bacteria to convert lignin monomers into valuable chemicals with a CRISPRi system, achieving a 4.89-fold increase in protocatechuate yield.